tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate
N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
CAS: 166815-96-9
Molecular Formula: C18H27NO5S
tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate - Names and Identifiers
tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C18H27NO5S |
| Molar Mass | 369.48 |
| Density | 1.174±0.06 g/cm3(Predicted) |
| Melting Point | 74-76℃ |
| Boling Point | 487.8±18.0 °C(Predicted) |
| Flash Point | 248.803°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | -1.94±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.526 |
tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate - Risk and Safety
| Hazard Class | IRRITANT |
tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate - Introduction
N-TERT-BUTOXYCARBONYL-4-PIPERIDINE is an organic compound whose chemical properties are as follows:
Nature:
-Molecular formula: C17H24N2O5S
-Molecular weight: 364.45g/mol
-Appearance: White or off-white crystalline powder
-Melting Point: 90-95 ℃
-Solubility: Soluble in esters, ethers, chlorinated hydrocarbons and other organic solvents
Use:
- N-TERT-BUTOXYCARBONYL-4-protecting group commonly used in organic synthesis. It can protect the amino group on the piperidine ring, and then remove the protecting group by acid or base treatment when necessary, so as to carry out the corresponding reaction.
-The compound can also be used as an intermediate in the pharmaceutical field and play an important role in the synthesis of drugs or drug research.
Synthetic method:
The preparation method of N-TERT-BUTOXYCARBONYL-4-(PIPERIDINE) can be carried out by the following steps:
1. Dissolve 1-piperidine methanol in dimethylformamide;
2. Adding appropriate amount of trimethylchlorosilane as catalyst;
3. Slowly add 4-(4-methylbenzenesulfonyl chloride) benzoate into the reaction system at low temperature;
4. After the reaction, process operations such as crystallization purification and drying are carried out.
Safety Information:
N-TERT-BUTOXYCARBONYL-4-(note) PIPERIDINE is an organic compound, the use of the following safety matters:
-Avoid contact with skin, eyes and mucous membranes, and use appropriate protective gloves, glasses and masks when working.
-Avoid inhaling its dust and ensure that it is operated in a well-ventilated environment.
-Store in a dry, cool place, away from fire and flammable substances.
-Pay attention to comply with laboratory safety practices and properly dispose of waste. For specific information or first aid, refer to the product's safety data sheet.
Nature:
-Molecular formula: C17H24N2O5S
-Molecular weight: 364.45g/mol
-Appearance: White or off-white crystalline powder
-Melting Point: 90-95 ℃
-Solubility: Soluble in esters, ethers, chlorinated hydrocarbons and other organic solvents
Use:
- N-TERT-BUTOXYCARBONYL-4-protecting group commonly used in organic synthesis. It can protect the amino group on the piperidine ring, and then remove the protecting group by acid or base treatment when necessary, so as to carry out the corresponding reaction.
-The compound can also be used as an intermediate in the pharmaceutical field and play an important role in the synthesis of drugs or drug research.
Synthetic method:
The preparation method of N-TERT-BUTOXYCARBONYL-4-(PIPERIDINE) can be carried out by the following steps:
1. Dissolve 1-piperidine methanol in dimethylformamide;
2. Adding appropriate amount of trimethylchlorosilane as catalyst;
3. Slowly add 4-(4-methylbenzenesulfonyl chloride) benzoate into the reaction system at low temperature;
4. After the reaction, process operations such as crystallization purification and drying are carried out.
Safety Information:
N-TERT-BUTOXYCARBONYL-4-(note) PIPERIDINE is an organic compound, the use of the following safety matters:
-Avoid contact with skin, eyes and mucous membranes, and use appropriate protective gloves, glasses and masks when working.
-Avoid inhaling its dust and ensure that it is operated in a well-ventilated environment.
-Store in a dry, cool place, away from fire and flammable substances.
-Pay attention to comply with laboratory safety practices and properly dispose of waste. For specific information or first aid, refer to the product's safety data sheet.
Last Update：2024-04-09 02:00:42
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